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Genetic factors influence key clinical features of migraines, such as earlier onset age, higher frequency in male patients, and increased medication usage (Pelzer et al., 2019)

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Combination Research Considerations The mechanistic non-overlap between Epitalon and GHK-Cu suggests potential research value in combination protocols: Upstream + downstream senescence targeting: Epitalon addresses telomere shortening (the upstream trigger of replicative senescence) while GHK-Cu suppresses SASP (the downstream consequence of established senescence) Circadian + antioxidant coverage: Epitalon restores melatonin circadian amplitude

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